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There's knowledge in the number

Quantitative Fetal Fibronectin

Let the numbers
tell her story

Preterm birth in Australia

The incidence of preterm birth continues to rise worldwide.* Approximately 8% of babies in Australia are born prematurely (<37 weeks) – that’s over 25,000 preterm births occurring annually or around 1 in 12 births.1

The causes are not fully understood, and in up to half of all preterm births, the cause remains unidentified. Although there are some related risk factors, the majority of women with traditional risk factors do not deliver early and of the patients who do, many do not have identifiable risk factors. Whether or not some risk factors are markers for other conditions and/or other risk factors is unknown.2

Traditional risk factors3

  • Previous preterm birth
  • Multiple pregnancy
  • Patient has undergone cervical cone biopsy or uterine abnormalities
  • Previous miscarriage/s during second trimester
  • Cervical length of 25mm or less
  • In vitro fertilisation (IVF)4
*Born too soon: the global action report on preterm birth, WHO, 2012.

Quantitative Fetal Fibronectin (fFN)

Know the number to calculate a plan

When a patient is experiencing symptoms of preterm labour, you need to determine if her risk of preterm birth is real or perhaps quite low. With Quantitative fFN testing, you can precisely measure the fetal fibronectin concentration to help quantify the risk of delivery before 34 weeks in both patients who have symptoms of preterm labour and high-risk patients. In a matter of minutes, understand the risk of preterm birth to help you construct an informed patient management plan.

The Quantitative Rapid fFN result should always be used in conjunction with information available from the clinical evaluation of the patient and other diagnostic procedures.6

About fFN

Fetal fibronectin acts as an adhesive glycoprotein at the maternal-fetal interface that bonds maternal membranes to fetal membranes.

It is a biomarker for preterm delivery, and is highly associated with risk of preterm delivery when present in cervicovaginal secretions.

Download fFN Specimen Collection Guide

Symptomatic Patients

Approved for collection between
22-36 weeks' gestation

For patients who have symptoms of preterm labour, the detection of fetal fibronectin concentrations can help you quickly determine the risk of delivery within 2 weeks.

Stratification of Preterm Birth Risk by fFN Concentration3

A clinical study evaluating fFN concentration showed that women with symptoms of preterm labour were 50 times more likely to deliver before 34 weeks with a test result of 500 ng/mL compared with < 10 ng/mL.2

Risk of delivery < 34 weeks in women with symptoms of preterm labour5

High-risk Patients

Approved for collection between
22-28 weeks' gestation

For high-risk asymptomatic patients, the detection of fetal fibronectin concentrations can help you construct an informed and timely management plan.

Spontaneous Preterm Birth Rates in Asymptomatic High Risk Women According to Quantitative Fetal Fibronectin Categories6

All comparisons for each gestational end point are statistically significant (p<0.01) except 10-29 ng/mL vs. 50-199 ng/mL and 200-499 vs. >500+ (p>0.1 for all gestational end points).

A more complete answer

In just 5 steps.

With the Rapid fFN PeriLynx System it's easy to get a quantitative answer in a matter of minutes.

  • Step 1Step 1

    Enter User ID, Rapid fFN 10Q Cassette Lot and Sample ID/Patient ID. When prompted, press ENTER.

  • Step 2Step 2

    Insert Rapid fFN 10Q Cassette into the analyser

  • Step 3Step 3

    Dispense sample into the Rapid fFN 10Q Cassette well.

  • Step 4Step 4

    Press START TEST and walk away.

  • Step 5Step 5

    Results ready in 10 minutes.

Request a copy of PeriLynx Installation and Training video

Order Information

To request or place an order, please contact Hologic Australia:
1800 264 073 | australia@hologic.com

Download fFN resource order form

Request PeriLynx or 10Q System Training video